Endocrine Abstracts

Objective: To report a case of hypogonadism reversal and spontaneous puberty in a craniopharyngioma patient who suffered from hypopituitarism as a result of complete surgical resection.Methods: A 13-year-old boy with hypopituitarism was evaluated for right testicular sensitivity.At the age of 6 the child presented with growth arrest and a craniopharyngioma causing pituitary insufficiency was diagnosed. Treatment with hydrocortisnon...

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

Background: Recent data suggest that disturbances in circadian clock functioning are implicated in the pathogenesis of type 2 diabetes (T2D), through alterations in plasma glucose levels, insulin secretion and sensitivity, energy intake, and genomic expression in liver and pancreas. This study aimed to assess a potential association between variants in clock genes and T2D risk in a population of Greek elderly people.Methods: In a case-control design, 125...

Background: Vitamin D receptor (VDR) in the presence of active calcitriol (1.25--dihydroxy vitamin D) acts as a transcription factor that modulates the gene expression oftransport proteins, which are involved in calcium metabolism. Accumulating evidence suggest apotential implication of vitamin D deficiency in the pathogenesis of diabetes mellitus. We aimed toassess whether variants in the VDR gene contribute to risk of Type 2 Diabetes Mellitus (T2DM).<p class="ab...